Bremelanotide Rx
Start provider review

FDA-approved drug

PT-141 is a real approval with modest numbers. We print both, then show you what the vials leave out.

Bremelanotide (Vyleesi) earned a genuine FDA approval in 2019 for low sexual desire in premenopausal women: desire scores rose 0.30 to 0.42 points more than placebo on a 1.2-to-6.0 scale, distress improved, and satisfying sexual events did not significantly change. The same label counts 40% nausea and a possibly permanent skin-darkening risk. Meanwhile the gray market sells 'PT-141' vials to men for performance, the exact uses the label rules out, on small 2004-to-2008 trials, two of which now carry journal integrity flags. Every number on this site links to its source.

Start provider reviewBrowse the guides
  • 1FDA-approved use, and we quote its exact boundary
  • 38fetch-verified sources, every one peer-reviewed or government
  • 15studies in the graded evidence table, species labeled on every row
  • 2male-use trials in that table carry journal integrity flags, and the rows say so

Online care, from intake to delivery

Bremelanotide care, made simple

Choose your plan, complete a private medical intake, and connect with a licensed provider. If prescribed, treatment ships discreetly to your door.

Bremelanotide care catalog product image
Compounded injectable treatmentPrepared after approval
Catalog image. Dispensed product and packaging may vary by pharmacy.

Your care plan includes

Everything you need to get started

From$153per month
Licensed providerMedical reviewIf prescribedTreatment includedAt no added costDiscreet shippingWhen you need itOrder support
Choose your planChange or cancel future refills anytime
Due today$170.10then monthly

Encrypted checkout • provider review required • shipping included

  1. 01
    Choose your planSelect the supply and refill preference that works for you.
  2. 02
    Complete your intakeShare your health history in our private, secure flow.
  3. 03
    Provider reviewIf appropriate, your prescription is prepared and shipped.

Prescription treatment requires an online medical evaluation. A provider will determine whether treatment is medically appropriate; approval is not guaranteed.

Key facts

  • StatusFDA-approved drug
  • SC bioavailability~100%source
  • Volume of distribution25.0 L (mean)source
  • Clearance6.5 L/hr (CL/F)source
  • Protein binding21%source
  • Dose plateauCmax plateaus at 7.5 mg SC (~4.3x approved dose)source
  • Excretion64.8% urine, 22.8% feces (radiolabel)source
  • ClassMelanocortin receptor agonist (cyclic heptapeptide alpha-MSH analog)FDA labelsource
  • Approved useAcquired, generalized HSDD in premenopausal womenFDA labelsource
  • Explicitly not indicatedMen; postmenopausal women; enhancing sexual performanceFDA labelsource
  • Dose1.75 mg SC autoinjector, at least 45 min before activityFDA labelsource
  • Half-lifeAbout 2.7 h (range 1.9 to 4.0)FDA labelsource
  • TmaxAbout 1.0 h (range 0.5 to 1.0)FDA labelsource
  • Desire effect vs placebo+0.30 and +0.42 points (scale 1.2 to 6.0); integrated +0.35Human RCTsource
  • Satisfying sexual eventsNo significant change vs placebo in either phase 3 trialFDA labelsource
  • Nausea rate40.0% vs 1.3% placeboFDA labelsource
  • Key contraindicationUncontrolled hypertension or known cardiovascular diseaseFDA labelsource
  • MoleculeC50H68N14O10, MW 1025.2 (free base), PubChem CID 9941379Chemical referencesource

Read the full Bremelanotide monograph

Browse by topic

Everything on PT-141 (bremelanotide), organized the way you research it.

Dosing13 articlesSourcing13 articlesEvidence13 articlesSafety9 articlesComparisons6 articles

Free Bremelanotide tools

Practical calculators and references, each scoped and sourced.

T-01Vyleesi label-limits checkerTurns the label's three numeric rules into an interactive check: enter doses already used this month, hours since the last dose, and minutes until anticipated activity; the tool reports whether a dose now would sit inside or outside each label rule, with the rule quoted and cited.T-02PT-141 side-effect odds explorerRenders the label's adverse-reaction table as an interactive comparison (Vyleesi vs placebo), with the nausea time course (first dose vs later doses), the anti-emetic numbers, and the discontinuation rates. Unique per-compound data component: every value is a label number with a claim id.T-03PT-141 study-dose explorerEvery dose any bremelanotide (or precursor Melanotan-II) trial actually tested, sortable by population, route, dose and year, with outcome, grade and integrity flags. Exists so any quoted 'PT-141 dose' can be checked against what was actually studied.

All guides

54 in-depth, individually cited guides.

Dosing 13 guides

Does PT-141 need to be refrigerated? storage guideUnopened PT-141 (bremelanotide) needs refrigeration; once mixed or in an auto-injector, storage rules change. Here's exactly what the label and studies support.Updated 2026-07-25Read guide →
PT-141 cycle length: how long to use bremelanotide, and whyPT-141 isn't cycled like a hormone. Here's what the Vyleesi trials actually tested for duration, dosing frequency, and when to stop.Updated 2026-07-25Read guide →
PT-141 dosage: how much bremelanotide to use and whenPT-141 (bremelanotide) is dosed at 1.75 mg by subcutaneous injection, taken as needed before sexual activity. Here's the full protocol and why it's dosed this way.Updated 2026-07-25Read guide →
PT-141 half life: how long bremelanotide lasts in the bodyPT-141's terminal half-life is about 2 to 2.7 hours, but its effect on desire can run 6 to 24 hours because the drug acts on brain receptors, not blood levels.Updated 2026-07-25Read guide →
PT-141 how to inject: a step-by-step clinical guideHow to inject PT-141 (bremelanotide) correctly: site, angle, timing before intimacy, and what the phase 3 trials actually showed about response rates.Updated 2026-07-25Read guide →
PT-141 injection sites: where and how it's givenPT-141 (bremelanotide) is injected subcutaneously in the abdomen or thigh, about 45 minutes before activity. Here's where, how, and what side effects to expect.Updated 2026-07-25Read guide →
PT-141 storage and shelf life: how to keep it stableHow to store PT-141 (bremelanotide) before and after reconstitution, how long it lasts, and the signs it has gone bad. Plain, practical guidance.Updated 2026-07-25Read guide →
PT-141 timeline: what to expect hour by hourPT-141 works over hours, not days. See when nausea, flushing, and desire effects hit, from the phase 3 trials that got Vyleesi approved by the FDA.Updated 2026-07-25Read guide →
How to reconstitute PT-141: a clear, careful protocol guideA plain, step-by-step look at how PT-141 (bremelanotide) is reconstituted, why sterile technique matters, and what the FDA-approved Vyleesi form actually looks like.Updated 2026-07-24Read guide →
PT-141 dosage calculator: how reconstitution math worksPT-141 dosage math explained: the FDA-approved dose is 1.75 mg by subcutaneous injection. See how reconstitution calculators work and why the numbers matter.Updated 2026-07-24Read guide →
PT-141 dosage chart: doses, units, and mL explainedPT-141 dosage chart based on the Vyleesi trials: 1.75 mg standard dose, timing, units vs mL conversion, and what happens if you take more.Updated 2026-07-24Read guide →
PT-141 how long does it last: onset, peak, durationPT-141 (bremelanotide) effects last roughly 16-24 hours after one dose, with libido effects peaking hours after injection. Here's what the trial data actually shows.Updated 2026-07-24Read guide →
PT-141 how to use: mixing, dosing, and injection stepsHow to reconstitute, mix, and inject PT-141 (bremelanotide) correctly, with the FDA-approved 1.75 mg dose from trial data and honest side effect timing.Updated 2026-07-24Read guide →

Sourcing 13 guides

How to verify PT-141 quality before you use itPT-141 sold outside FDA-approved Vyleesi is unregulated. Here's how to check purity, sourcing, and red flags before you trust a vial of bremelanotide.Updated 2026-07-25Read guide →
PT-141 prescription requirements: what you actually needYes, PT-141 (bremelanotide) requires a prescription. Here's what a real workup involves, why it's Rx-only, and what makes a source legitimate versus risky.Updated 2026-07-25Read guide →
Best place to buy PT-141: pharmacy, telehealth, and safety realityPT-141 (bremelanotide) is FDA-approved as Vyleesi. Only prescriptions from licensed providers and filling pharmacies are legal. Here's how sourcing actually works.Updated 2026-07-24Read guide →
Is PT-141 FDA approved? the honest answerYes, but only one version. Vyleesi (bremelanotide) got FDA approval in June 2019 for HSDD in premenopausal women. Here's exactly what that covers.Updated 2026-07-24Read guide →
PT-141 certificate of analysis explained: what to checkA PT-141 certificate of analysis should show identity, purity %, and testing method. Here's what real ones look like and why compounded PT-141 isn't FDA-checked.Updated 2026-07-24Read guide →
PT-141 compounding pharmacy vs research supplier: what's legalCompounding pharmacies dispense under prescription, research suppliers sell unregulated chemicals. Only one is lawful for human use, and the difference matters.Updated 2026-07-24Read guide →
PT-141 cost and pricing: what you'll actually pay in 2026PT-141 costs $950, $1,550 for FDA-approved Vyleesi, $50, $300 for compounded monthly doses. What drives the price, insurance rarely covers, where to compare.Updated 2026-07-24Read guide →
PT-141 legal status: where it's approved, where you can't get itPT-141 (bremelanotide) is FDA-approved as Vyleesi for premenopausal women with HSDD. Compounded versions exist in a gray zone; off-label use and online sources carry real legal and safety risk.Updated 2026-07-24Read guide →
PT-141 peptide for men near me: prescribers, legality, and how it worksPT-141 (bremelanotide) is FDA-approved for women but prescribed off-label for men. How the melanocortin pathway works, who can prescribe, and legal sourcing.Updated 2026-07-24Read guide →
PT-141 peptide for sale on Amazon: what you need to knowPT-141 (bremelanotide) is FDA prescription-only; Amazon listings are unregulated research chemicals or mislabeled supplements. What's safe and legal.Updated 2026-07-24Read guide →
Pt-141 peptide near me: what to actually look forSearching "pt 141 peptide near me"? Here's what matters more than location: legal source, real dosing, and honest side effect data before you buy.Updated 2026-07-24Read guide →
PT-141 peptide therapy near me: provider options and costsPT-141 (bremelanotide) is FDA-approved as Vyleesi; most 'peptide clinics' offer compounded versions at $150-350/month. What you need to know about providers.Updated 2026-07-24Read guide →
PT-141 purity and testing: what compounded peptide buyers need to knowNo FDA purity mandate exists for compounded PT-141. What testing matters, which certificates mean nothing, and how to avoid underdosed or contaminated product.Updated 2026-07-24Read guide →

Evidence 13 guides

PT-141 before and after claims: what the evidence showsPT-141 (bremelanotide) before and after claims reviewed against real trial data. What Vyleesi actually did in phase 3 trials, and what results really mean.Updated 2026-07-25Read guide →
PT-141 clinical trials: what the Vyleesi studies actually showHow the two RECONNECT phase 3 trials led to FDA approval of bremelanotide (Vyleesi): real response rates, side effects, and what critics dispute.Updated 2026-07-25Read guide →
PT-141 peptide: how it works, dosing, and side effectsPT-141 peptide (bremelanotide) works on brain desire circuits, not blood flow. FDA approved as Vyleesi for HSDD. Here's the real mechanism, dosing, and side effect data.Updated 2026-07-25Read guide →
PT-141 results: what the clinical research actually showsIn FDA trials, about 25% of women reported meaningfully higher desire on PT-141 vs 17% on placebo. Here's what the studies measured and what they didn't.Updated 2026-07-25Read guide →
Does pt-141 nasal spray work, or just the injection?Short answer: the FDA approval is for an injection (Vyleesi), not a nasal spray. Here's what the trial data actually shows and why the spray form is unproven.Updated 2026-07-24Read guide →
How long does PT-141 take to work: onset timelinePT-141 (bremelanotide) starts working in about 45 minutes to 6 hours after injection. Here's the real onset window, based on the phase 3 trial data.Updated 2026-07-24Read guide →
How to get PT-141 (bremelanotide) legally, the real optionsPT-141 is FDA-approved as Vyleesi by prescription only. Here's how prescriptions work, what a legit path looks like, and why gray-market vials are risky.Updated 2026-07-24Read guide →
How to take pt-141 peptide: injection, timing, dosinghow to take pt-141: subcutaneous injection, 45 minutes before activity, no more than once in 24 hours or 8 doses a month, per fda-approved vyleesi labeling.Updated 2026-07-24Read guide →
PT-141 animal studies vs human evidence: what translatesPT-141 works centrally in both animals and humans, but effect sizes differ. Phase 3 trials showed modest benefit; we compare preclinical and clinical data.Updated 2026-07-24Read guide →
PT-141 human studies: what the bremelanotide trials showPT-141 human studies explained: the RECONNECT phase 3 trials, response rates, nausea and flushing rates, and what got bremelanotide FDA approval as Vyleesi.Updated 2026-07-24Read guide →
PT-141 mechanism of action: how bremelanotide works in the brainPT-141 (bremelanotide) works through brain melanocortin receptors, not blood vessels like sildenafil. Here's the actual neuroscience, from receptor to response.Updated 2026-07-24Read guide →
PT-141 stack with other peptides: what works and what doesn'tBremelanotide (PT-141) acts centrally on melanocortin receptors. We review stacking rationale, interaction data, and why most combinations lack evidence.Updated 2026-07-24Read guide →
What does PT-141 actually do in the bodyPT-141 (bremelanotide) works on brain melanocortin receptors, not blood vessels. Here's what it actually does, backed by the phase 3 trial data.Updated 2026-07-24Read guide →

Safety 9 guides

Is PT-141 safe? what the FDA trials actually foundPT-141 (bremelanotide) is FDA-approved as Vyleesi. Nausea hit up to 40% of trial users. Here's the real safety data on side effects, heart risk, and who should skip it.Updated 2026-07-25Read guide →
PT-141 and athletes: is bremelanotide banned in sports?WADA does not list bremelanotide as prohibited, but athletes should still know how PT-141 works before using it. Here's the honest breakdown.Updated 2026-07-25Read guide →
PT-141 and blood work: what actually gets checkedDoes PT-141 (bremelanotide) require blood work? Here's what the trials monitored, what your doctor should check, and why blood pressure matters more than labs.Updated 2026-07-25Read guide →
PT-141 contraindications: who should not use bremelanotidePT-141 (Vyleesi) isn't safe for everyone. Uncontrolled hypertension, cardiovascular disease, and pregnancy are key contraindications. Full breakdown here.Updated 2026-07-25Read guide →
PT-141 drug interactions: what actually needs cautionPT-141 (bremelanotide) works on brain receptors, not blood vessels. Here's what interacts, what doesn't, and why the naltrexone warning matters.Updated 2026-07-25Read guide →
PT-141 long term side effects: what the trial data showsNausea hit up to 40% of users in phase 3 trials. Here's what's known about PT-141 long term side effects, blood pressure risk, and what's still unstudied.Updated 2026-07-25Read guide →
PT-141 side effects: nausea, flushing, and what's normalNausea hits up to 40% of Vyleesi users in trials. Here's the real side effect data on PT-141 (bremelanotide), what's common, what's rare, and what needs a doctor.Updated 2026-07-25Read guide →
PT-141 in women: how bremelanotide works, dosing, and side effectsPT-141 (bremelanotide) is FDA-approved for low desire in premenopausal women at 1.75 mg subcutaneous. How it works centrally, dosing and side effects.Updated 2026-07-24Read guide →
PT-141 peptide side effects: what the trials actually foundNausea hit 40% and flushing 20% in PT-141 trials. Here's what the FDA data on Vyleesi side effects actually shows, and what it means for dosing.Updated 2026-07-24Read guide →

Comparisons 6 guides

PT-141 vs Viagra: how the two arousal drugs actually differPT-141 works on brain desire circuits; Viagra works on penile blood flow. Compare mechanism, FDA status, side effects, and who each drug actually helps.Updated 2026-07-25Read guide →
PT-141 vs Addyi: mechanism, dosing, and which one works fasterPT-141 works centrally in 45 minutes via injection; Addyi requires daily pills for 8 weeks. Compare efficacy, side effects, and cost with trial data.Updated 2026-07-24Read guide →
PT-141 vs Cialis: how these two libido drugs actually differPT-141 works in the brain, Cialis works in blood vessels. Compare mechanism, sex-specific approval, side effects, and timing for these two very different drugs.Updated 2026-07-24Read guide →
PT-141 vs kisspeptin: how these two desire peptides differPT-141 (bremelanotide) is FDA-approved for HSDD with a melanocortin mechanism. Kisspeptin is investigational. Here's how they compare on evidence, safety, and use.Updated 2026-07-24Read guide →
PT-141 vs oxytocin: mechanism, efficacy, and clinical use comparedPT-141 acts centrally on melanocortin receptors; oxytocin works peripherally and centrally. Compare mechanisms, evidence, dosing, and practical differences.Updated 2026-07-24Read guide →
PT-141 vs Vyleesi: same molecule, different sourcing and oversightPT-141 and Vyleesi are the same drug (bremelanotide). Vyleesi is FDA-approved, pre-filled, and prescribed. PT-141 is compounded. Here's what changes.Updated 2026-07-24Read guide →

Get the real-numbers brief before you believe a vial pitch

One email: the exact phase 3 numbers including the null endpoint, the label limits, the nausea and pigmentation odds, and the autoinjector-vs-vial difference. Cited, No dosing advice by email. Unsubscribe anytime.

Free. No spam, unsubscribe anytime. Your address is used for this brief and nothing else.

Start provider review